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Studies using IL-23-induced mouse models of psoriasis show that the targeted deletion of EP2 and EP4 receptors on T cells results in the suppression of Th17 cell accumulation and associated cutaneous inflammation (55)

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however, there were no significant changes in fasting insulin and insulin sensitivity index between groups [37]

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FASEB J 21:36663676

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Blutstein T, Haydon PG (2013) The importance of astrocyte-derived purines in the modulation of sleep

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